NO Synthase
Nitric oxide synthases; NOS
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.
NO Synthase Isoform Specific Products
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NO Synthase Inhibitors
(737)
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NO Synthase Agonists
(5)
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NO Synthase Antagonists
(4)
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NO Synthase Activators
(112)
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NO Synthase Modulators
(13)
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NO Synthase MDM2 Inhibitor
(1)
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NO Synthase Inducers
(7)
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NO Synthase Controls
(6)
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NO Synthase Substrates
(2)
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NO Synthase Ligand
(1)
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NO Synthase Related Products (987)
Related Products (987)
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Antibodies (6)
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NO Synthase Isoform Comparison
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O-Methylnotoptol
0 ImagesCat. No.: HY-187049CAS No.: 88206-50-2O‑Methylnotoptol is a Coumarin (HY-N0709) isolated from the roots and rhizomes of Notopterygium incisum. O‑Methylnotoptol inhibits LPS‑induced nitric oxide production in RAW 264.7 murine macrophages with an IC50 value of 23.9 μM.
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Nω-Propyl-L-arginine (Standard)
0 ImagesSynonyms: N-omega-Propyl-L-arginine (Standard)Nω-Propyl-L-arginine (Standard) is the analytical standard of Nω-Propyl-L-arginine (HY-102062). This product is intended for research and analytical applications. Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).
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Cinnamyl Alcohol-d5
0 ImagesCat. No.: HY-Y0078SCAS No.: 1044940-87-5
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VR11 aptamer
0 ImagesCat. No.: HY-177406VR11 aptamer is a DNA-based TNF-α inhibitor with a KD of 7.0 nM. VR11 aptamer prevents TNFα-induced apoptosis and NO production. VR11 aptamer has non-immunogenicity and does not raise immune responses when injected intraperitoneally into C57BL/6 mice model. VR11 aptamer can be used for inflammatory diseases research.
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α-Guanidinoglutaric acid
0 Imagesα-Guanidinoglutaric acid is a guanidino compound first found in cobaltinduced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric acid induces epileptic seizures in rats after intraventricular administration.
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Agnuside (Standard)
0 ImagesSynonyms: Agnoside (Standard)Agnuside (Standard) is the analytical standard of Agnuside. This product is intended for research and analytical applications. Agnuside is used in the study of asthma, inflammation, and angiogenic diseases. Agnuside is an orally active compound that can be extracted from Vitex negundo.
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3β,7β,15α-Trihydroxy-4-(hydroxymethyl)-11,23-dioxo-lanost-8-en-26-oic acid
0 ImagesCat. No.: HY-N13701CAS No.: 1961358-03-13β,7β,15α-Trihydroxy-4-(hydroxymethyl)-11,23-dioxo-lanost-8-en-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum, and it inhibits nitric oxide (NO) production in BV-2 microglial cells induced by lipopolysaccharide (LPS, HY-D1056), with an IC50 of 4.15 μM.
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Dehydroevodiamine hydrochloride (Standard)
0 ImagesCat. No.: HY-N6029RCAS No.: 111664-82-5Dehydroevodiamine hydrochloride is isolated from the leaves of Evodia rutaecarpa.
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Ethylnotopterol
0 ImagesCat. No.: HY-N20742CAS No.: 158269-48-8Ethylnotopterol is a coumarin found in the roots and rhizomes of Notopterygium incisum and an inhibitor with an IC50 value of 18.1 μM for LPS-induced nitric oxide production. Ethylnotopterol blocks LPS-induced nitric oxide production in macrophage cells.
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Cornuside (Standard)
0 ImagesCat. No.: HY-N0631RCAS No.: 131189-57-6Cornuside (Standard) is the analytical standard of Cornuside (HY-N0631). This product is intended for research and analytical applications. Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation.
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Triflusal (Standard)
0 ImagesTriflusal (Standard) is the analytical standard of Triflusal (HY-B0531). This product is intended for research and analytical applications. Triflusal is an orally bioavailable, blood-brain barrier-permeable dual Cyclooxygenase-1 (COX-1)/cAMP phosphodiesterase inhibitor. Triflusal inhibits platelet aggregation, NF-κB activation, iNOS activity, and prostaglandin synthesis in ischaemic tissue. Triflusal stimulates neutrophil nitric oxide production, eNOS protein expression, and cNOS activity. Triflusal alleviates cerebral ischemic injury in rats and ameliorates pathological lesions and related gene expression in transgenic Alzheimer’s disease models. Triflusal can be used for the research of thromboembolic/ischemic cardiovascular and cerebrovascular diseases, and Alzheimer’s disease.
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L-Canavanine sulfate (Standard)
0 ImagesL-Canavanine (sulfate) (Standard) is the analytical standard of L-Canavanine (sulfate). This product is intended for research and analytical applications. L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
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Licoflavanone
0 ImagesCat. No.: HY-N10133CAS No.: 119240-82-3Synonyms: 3′-PrenylnaringeninLicoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms.
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Paeonidanin
0 ImagesCat. No.: HY-187062CAS No.: 209969-75-5Paeonidanin is a monoterpenoid glycoside with an IC50 > 100 μM for nitric oxide production inhibition in lipopolysaccharide-activated microglia and macrophages. Paeonidanin suppresses lipopolysaccharide-induced production of nitric oxide, interleukin-6, and tumor necrosis factor alpha in macrophages and microglia.Paeonidanin can be used for the research of inflammation.
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Corydaldine
0 ImagesCorydaldine is a alkaloid. Corydaldine inhibits the production of NO in the BV2 cell line when stimulated by LPS.[1]
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AR-C102222
0 ImagesCat. No.: HY-12122CAS No.: 253771-21-0AR-C102222 is a spirocyclic fluoropiperidine quinazoline selective iNOS inhibitor. AR-C102222 can be used for the research of neuropathic pain.
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Anti-inflammatory agent 65
0 ImagesCat. No.: HY-149724CAS No.: 3035442-58-8Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response.
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N-(p-Coumaroyl) Serotonin (Standard)
0 ImagesCat. No.: HY-129440RCAS No.: 68573-24-0N-(p-Coumaroyl) Serotonin (Standard) is the analytical standard of N-(p-Coumaroyl) Serotonin (HY-129440). This product is intended for research and analytical applications. N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure.
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Lubiprostone (Standard)
0 ImagesCat. No.: HY-B0679RCAS No.: 136790-76-6Synonyms: RU-0211 (Standard); SPI-0211 (Standard)Lubiprostone (Standard) is the analytical standard of Lubiprostone. This product is intended for research and analytical applications. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research.
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FR260330
0 ImagesCat. No.: HY-122063CAS No.: 442198-67-6FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC50 of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056)-induced inflammatory diseases in rats model.
